📋 Tender Overview
De Novo Synthesis Of Fluoroarenes And Fluoro(Hetero)Arenes
Historically, One Of The Biggest Challenges In Synthetic Organic Chemistry Has Always Been To Synthesize Fluoroarenes (Ar-F) And Fluoroheteroarenes (Het-F) From Cheap, Readily Available Starting Materials, As Fluorination Has Always Concerned Synthetic Chemists Due To Either Undesirable Safety Of Reagents, Low Selectivities Or Poor Reactivities. Since Fluoroaryl- (Ar-F) And Fluoroheteroaryl- (Het-F) Are The Most Common Fluorinated Motives Among Pharmaceuticals Development Of A Completely Novel Synthetic Strategy Would Be Of Great Importance To The Research Community. De Novo Construction Of Fluorobenzene Using C1F1 Synthons Is An Unprecedented Process. We Foresee That Little Explored Monofluorinated Ortoformates (Ro)3Cf (Fofs) Could Be A Synthetic Equivalent To Access C1F1 Synthon For Annulation Reactions.
Funded Under
Widening Participation And Spreading Excellence
Total Cost
€ 0,00
Eu Contribution
€ 162 499,20
Coordinated By
Latvijas Organiskas Sintezes Instituts
Latvia
Start Date
1 April 2025
End Date
31 March 2027
Objective
Historically, one of the biggest challenges in synthetic organic chemistry has always been to synthesize fluoroarenes (Ar-F) and fluoroheteroarenes (Het-F) from cheap, readily available starting materials, as fluorination has always concerned synthetic chemists due to either undesirable safety of reagents, low selectivities or poor reactivities. Since fluoroaryl- (Ar-F) and fluoroheteroaryl- (Het-F) are the most common fluorinated motives among pharmaceuticals development of a completely novel synthetic strategy would be of great importance to the research community. De novo construction of fluorobenzene using C1F1 synthons is an unprecedented process. We foresee that little explored monofluorinated ortoformates (RO)3CF (FOFs) could be a synthetic equivalent to access C1F1 synthon for annulation reactions.
