📋 Tender Overview
Period of StudyOct 17 - Sep 21FunderBBSRCProject StatusActiveProject CategoryStudentshipProject Reference1903455Consumption of unhealthy diets is exacerbating the burden of age-related ill health in ageing populations. Such diets can programme mammalian physiology to cause long-term detrimental effects. Recently we have shown that in Drosophila melanogaster an unhealthy high-sugar diet in early adulthood programmes lifespan to curtail later-life survival despite subsequent dietary improvement. Excess dietary sugar promotes insulin-like signalling inhibits dFOXO - the Drosophila homologue of Forkhead Box O FOXO transcription factors - and represses expression of dFOXO-target genes encoding epigenetic regulators. This project aims to understand the epigenetic regulation downstream of dFOXO and nutrition in order to elucidate the mechanisms that program animal lifespan.
